Peter A Noble - Professor of Microbiology

Peter A Noble, PhD

Tucson, Arizona

Cell: 206-409-6664




peteranobleResearch Interests and Goals

During graduate, post-doc, and early faculty years, I conducted basic research in molecular biology, microbial ecology, and bioinformatics. My research really took off at the University of Washington (UW). I wanted to study microbial dynamics in ecosystems using high-throughput DNA microarrays -- however, I quickly discovered that they yield inconsistent output. As a consequence, my research shifted to understanding the physicochemistry of microarrays in order to provide a solution to the inconsistency problem. After nine years, my team produced a large body of research on the physicochemistry underpinnings of DNA microarrays and, from that newfound knowledge, developed an accurate and statistically robust approach to quantify genes and transcripts in biological samples (Gene Meters) (PlosOne 9:e91295; Nucl. Acids Res. 41:2779; Open Biol. 7:160267; Commun. Integr. Biol. 10:e1329785).

My current research builds on these accomplishments and is highly interdisciplinary: (1) the death microbiome in humans, (ii) postmortem gene expression in zebrafish and mice, (iii) oral microbiome transplantation for the prevention of periodontitis, (iv) biofilm development on aeration diffusers in wastewater treatment plants, and (v) prevention of biocorrosion in dental implants.